We live on a placid island of ignorance in the midst of black seas of infinity, and it was not meant that we should voyage far. The sciences, each straining in its own direction, have hitherto harmed us little; but some day the piecing together of dissociated knowledge will open up such terrifying vistas of reality, and of our frightful position therein, that we shall either go mad from the revelation or flee from the deadly light into the peace and safety of a new dark age.
The Call of Cthulhu
One way of looking at human creativity is as a process of pulling balls out of a giant urn. The balls represent possible ideas, discoveries, technological inventions. Over the course of history, we have extracted a great many balls – mostly white (beneficial) but also various shades of gray (moderately harmful ones and mixed blessings). [...] What we haven’t extracted, so far, is a black ball: a technology that invariably or by default destroys the civilization that invents it. The reason is not that we have been particularly careful or wise in our technology policy. We have just been lucky.
The Vulnerable World Hypothesis