The Protean flies through the positive energy plane, deeper than any conventional creature could possibly survive, but that is one of its Quirks. A weirdly rare Quirk, but that just made it better.
The protean ceases to exist, soul annihilated completely.
Proteans with E± Quirks need to remain extinct, even if by their nature proteans resist such a fixed status as 'extinct'.
Well... they resist for now, at least.
The protean did something. That could be trouble. Did the protean know what it did?
This limits understanding, which limits response. It was very deep though, deep enough that—there.
That should fix most things, and no one else should be able to detect it.