This is Marvel comic book universe Deadpool. In the canon continuity we're loosely around Agency X era - post-Cable & Deadpool but before Evil Deadpool.
This should make things fairly unconfusing to readers who are only familiar with the movies. Salient differences in the setting will mostly be explained; the only thing that might be confusing without context is the references to the specific features of Deadpool in the comic medium. So:
1: Deadpool's speech bubbles are yellow, instead of the customary white.
There are some scans here which give you an idea: