It's a very long and very tense and stressful three hours.
At 11:35 pm Halthis manages to wean the epinephrine infusion down to zero. Finally. She is SO pleased with herself about this. Kalorm's heart rate seems to be pleased as well; he's hanging in there at 80 bpm, and his blood pressure is still hanging on in the vicinity of 80/50 (not great, but acceptable). His oxygenation isn't amazing - 88% or 89% - but, again, Treatment Planning considers that acceptable.
They're checking (partial) lab panels every hour. Kalorm's lactate has stalled out at 50% higher than the top of the normal parameters and refuses to go any lower, but his inflammatory markers continue to inch downward. (Not very fast - at this rate it would take weeks to get all the way back to normal - but better than an increase.) His electrolytes are stable. His creatinine is increasing again but that's more indicative of the drugs affecting his kidneys than of underlying damage. His white blood cell counts at least aren't getting any worse.
His hemoglobin is still just baaaarely below the normal reference range after the first blood transfusion. Treatment Planning is not delighted with this; in a patient with healthy bone marrow, they would let it slide even given his other risk factors, but Kalorm is separately at pretty high risk of developing worsening anemia over the next week before his bone marrow production is recovered. They'd like to give him another top up, not a full standard unit of blood but about 75% of one, over 90 minutes, pause if his lungs don't like it.
...Kalorm's lungs do NOT like it. About 45 minutes in, his O2 saturation starts dropping. Halthis obviously pauses the blood transfusion immediately while she figures out if it's related, but even so, within 5 minutes she's up to 100% oxygen concentration on the ventilator and his O2 saturation is still at 81%. Treatment Planning does not think this is acceptable. They want to give him more bronchodilators - even though the good ones will inevitably stimulate his sympathetic nervous system and not be great for his heart - and they want to bump the ventilator pressures up a notch.
The bronchodilators don't do much, but increasing the pressures roughly fixes the oxygenation problem! They eventually get back up to 87%, at which point Treatment Planning is willing to declare that fiiiiiine that is good enough for now.
His heart hates it, though! On the ultrasound imagery - which Treatment Planning fortunately requested they follow in real time - it immediately tanks his preload, the amount of blood managing to fill his atria and ventricles before the heartbeat. It's not helping that his heart rate is feeling the bronchodilators and is now up at 90.
Treatment Planning really doesn't want to restart the epinephrine, but they're pretty maxed out on everything else, and Kalorm's rate of irritable ectopic beats over the last hour is negligible. They'll try easing down the anti-arrhythmics dose by 25%.
This goes fine for a few minutes! Great, even! Kalorm's heart rate goes up some more, but stops at around 100, and his blood pressure is the best it's been all night, approaching 90/60.
- at 12:19 am, he goes into rapid atrial fibrillation, with a very irregular heart rate averaging to around 160.
He's actually not otherwise much more unstable! Atrial fibrillation is a less functional rhythm, he's losing the benefit of the atrial 'kick' that helps load up more blood into his ventricles to be sent onward, but Kalorm's left ventricle seems to be coping okay, and his blood pressure hangs on at 85/55.
(It's still pretty bad for him longer-run. His ventricles, confusedly trying to follow the chaotic electrical pattern higher up and taking random spikes in it as cues, are beating way too fast, so his heart is working harder, and meanwhile blood is pooling and hanging out being gently massaged by his pointlessly wriggling atria. If they let it do that for long he's definitely going to develop a blood clot, which they can't intervene to prevent because he's still slowly bleeding in his gut and it's not safe to give him any anticoagulation.)
Treatment Planning thinks that the main provoking factor here was actually the bronchodilators. Which didn't help his lungs much anyway, so how about they don't try that again. They're going to hold off on re-increasing the anti-arrhythmic infusion, since his cardiac muscle contractility and thus stroke volume per beat seems to benefit a lot from the decrease. They'll try cardioverting him back to a normal rhythm with an electric shock. This is risky, because it might send him into a worse arrhythmia, but it's also risky to try to convert him back with drugs, because they might drop his blood pressure to an unsustainable degree - at which point his heart will quickly stop getting enough blood back to pump, and there's a downward-spiral-attractor to slip into pulseless electrical activity, which has a worse prognosis than a shockable pulseless rhythm.
It takes seven minutes of clock time from the a-fib onset, and three shocks (each of which is a terrifying dice roll for everyone in the room) but they manage to get him back into normal sinus rhythm.
(The number of people in the room at this point is four. Halthis finds this pretty nerve-wracking, but Treatment Planning doesn't think this is an emergency worth waking Merrin for, and having any more people than that will inevitably make noise. As it is, they coordinate in complete silence via subvocalization microphones, while the other four backup medtechs hover next door.)
Kalorm's heart rate bounces around for a while but eventually re-stabilizes at 85.
By 1:05 am his blood pressure is at 100/60, mean arterial pressure of 73. Treatment Planning doesn't incredibly trust this, but when he's still there at 1:15, they propose easing down on the angiotensin II.
Kalorm's blood pressure...doesn't actually change much, even though by 1:40 am they're down to 50% of the previous max dose. He stays solidly between 95/55 and 100/60.
It's unclear if the main positive factor here is a more functional left ventricle reducing the congestion in his pulmonary circulation, or a slightly lower total fluid intake per hour, or a slightly higher urine output per hour (his body is definitely responding to the decreased kidney-yelling and he pees over 60 ml during a 30 minute period), or just the higher ventilator pressures eventually being felt. But by 2 am, when Kerrin arrives to take over, Kalorm's O2 saturation is mostly back above 90%. He's also put out 90 ml of urine in the last hour.